"Fermenkol" and "Kontraktubeks": comparison, differences and which is better

Indications for use and methods of using the drug

Indications for use and methods of application of Fermenkol are varied. Below you will learn more about each problem and methods for solving it using this tool.

Burns

A burn is a destruction of the skin due to the influence of high temperatures, chemical liquids or radiation.

During the process of wound regeneration after a burn, active formation of connective tissue is observed, within which pathological collagen begins to form. Fibrils of abnormal collagen randomly intertwine and stick together, intertwine with elements of hyaluronic acid, and as a result, a solid and solid structure is formed.

The main task of conservative treatment of a burn surface is to destroy excess collagen. The use of Fermenkol gel and solution is carried out according to the scheme selected by the attending physician, and the period of use will depend on the age of the scar.

When using the gel, 1-2 courses are most often prescribed lasting from 30 to 40 days. When prescribing a solution, different concentrations and number of courses can be chosen; these indicators will depend on the severity of the patient’s condition.

Post-acne

Fermenkol Elactin

After acne, scar tissue and pigmentation can form on the skin, which brings aesthetic discomfort.

If you start treating post-acne as early as possible, you can restore the original healthy and blooming appearance of the skin, and accordingly, the result will not be long in coming.

When using the drug, you can achieve almost complete cleansing of the skin from scars. The scar itself becomes much smaller in size, the connective tissue softens and its height decreases. The patient ceases to feel itching, pain and burning, and the scar tissue itself takes on the color of nearby skin, and is almost invisible.

Electrophoresis with Fermenkol allows you to achieve quick and high-quality results in scar correction than using only the gel form. When using the gel, 1-4 courses lasting from 30 to 40 days are prescribed, and if you use the liquid form, then it is necessary to carry out from 5 to 15 electrophoresis procedures with a certain concentration.

If atrophy of more than 50% of the skin is observed, then it is better to use Fermencol Elactin.

Related article: How to remove acne scars

Scars after surgery

Unfortunately, almost every person has undergone surgery in their life and received an unpleasant reminder of this in the form of a scar. If you do not treat and eliminate this problem, then an aesthetically unsightly scar may form.

Fermenkol solution and gel can be used immediately after healing of damaged tissues, namely after 14-21 days.

It is recommended to alternate phonophoresis and electrophoresis using the gel for a course of 30 to 40 days. These manipulations make it possible to deliver the collagenolytic enzyme complex to the scar tissue as quickly and efficiently as possible. When ultrasound and electric current affect the affected tissues, the processes of diffusion of the collagenolytic complex in the deep layers of scar tissue begin to increase, and as a result, the reduction of abnormal collagen increases.

You may be interested in: Methods for removing post-operative scars

Using fermenkol for stretch marks

Photo taken from the resource Otzovik.com

A separate paragraph of the article will describe the use of medicine to combat stretch marks.

To combat such skin defects as stretch marks, they released a separate form of Fermenkol with the Elactin prefix. In terms of effectiveness and final results, experts equate this medicine to a laser method for removing stretch marks. In addition, the following effects can be distinguished:

• renews 90% of affected skin;
• restores the homogeneous structure of the skin, evens out its shade;
• the firmness and elasticity of the epidermis increases;
• direct effect on scar tissue, since stretch marks are atrophic scars.

Fermenkol for eliminating stretch marks has a complex effect on problem tissues. Pathological collagen is destroyed and the skin is completely restored.

When using electrophoresis and phonophoresis techniques, the pharmacological activity of the active substances increases, and as a result, damaged skin fibers are restored much faster.

The mechanism of complex action of Fermenkol

Fermenkol has a complex effect on the main components of scar tissue and can be used as monotherapy.4

Fermenkol exhibits selective activity towards pathological collagen, undergoes deep and complete hydrolysis of the peptide bonds of excess collagen in scar tissue, and also ensures deep hydrolysis of hyaluronic acid in the excess extracellular matrix.

As a result of the effect of Fermenkol on dehydrated scar tissue, its hydration (moistening) parameters approach those characteristic of healthy skin.9

Thanks to the complex effects of Fermenkol, the anti-scar effect is achieved in the shortest possible time .

Scars are a protective reaction of the body. They occur at the site of cuts, burns, inflammations, and also after operations. When any wound heals, rapid synthesis of connective tissue occurs, in which sometimes pathological collagen is synthesized instead of healthy collagen. A rough redundant scar is formed. In such a scar, pathological collagen fibrils randomly intertwine and grow together, bind to hyaluronic acid fibers, forming a single rigid structure.

In order to get rid of an unsightly scar , you need to destroy pathological collagen and hyaluronic acid.

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Mechanism of action of Fermenkol

Outline gel for biorevitalization advantages of this drug
The main ingredients that make up the product have high activity, designed to reduce the growth and production of collagen in the skin, because scars form due to excessive collagen production. Scars of keloid and hypertrophic origin are formed due to an unexplained failure in collagen production. As a result, the substance begins to be produced in excessive quantities, and as a result - a scar.

The active ingredient of Fermenkol is collagenase, which selectively affects only pathological collagen contained only in healed tissue structures of keloid and atrophic scars, thereby destroying them and reducing the affected area. The manufacturer states that the drug does not interact with healthy collagen in unaffected tissues.

It follows from this that the enzymatic complex is capable of hydrolyzing the fibrous structures of elastin and collagen, with their subsequent breakdown into single amino acids. In addition, polysaccharides are involved in the hydrolysis reaction, namely hyaluronic acid, which is also found in scar tissue.

The drug affects scars that have formed no later than two years, since scar tissue retains its activity only until this period.

Contractubex

A therapeutic drug to eliminate inflammation, blood clots and resolve scars. Contractubex is produced in the form of a gel with a characteristic shade and smell. It penetrates deeply into all layers of the skin, the muscular-ligamentous corset, right down to the bone tissue. The drug has the property of regenerating damaged tissues, promoting their rapid recovery. The treatment complex was developed using selective technology, that is, the active substance acts exclusively on damaged cells, scar formations and the inflammatory process.

Mechanism of action

The prescription composition of the medicine includes Serae onion extract, heparin and allantoin. This complex in certain proportions has fibrinolytic, anti-inflammatory, thrombolytic and keratolytic effects. The main target or target of the drug is damaged tissue. Adhering to a specific treatment regimen, Contractubex enhances the regenerative process, stopping the proliferation of connective tissue (keloid fibroblasts). When using this remedy locally, tissue hyperplasia is not allowed. Our experts from the journal found that when patients used this remedy, only one case out of 50 patients studied was not treatable. The reason for this delay is chronic diseases of many systems and organs, that is, a weakened body with slow reactions and metabolism. For the remaining 49 patients, transepidermal heparinization eliminated inflammation and excess connective tissue in the affected area.

Indications and contraindications for Contractubex

The use of the drug in the form of a gel is recommended for all patients without age or gender restrictions. The drug is indicated for children aged 4-5 years, if prescribed by the attending physician. It is used even for chronic diseases of systems and organs, there are no exceptions.

The gel-based drug is used for:

keloid and hypertrophic scars, scars of various etiologies and pathogenesis;

the last stage of deforming arthrosis with contractures and complete ankylosis;

contractures of ligaments and muscles;

skin stretch marks of any location.

The only contraindications are allergic reactions to the transepidermal heparin drug and pregnancy. If, upon first use, red spots on the skin or a rash appear, Contractubex is canceled. In this case, you can use the comparative information of Imoferase or Contractubex: comparison of drugs and which is better, and switch to a similar local medicine.

Special instructions! The regeneration and resorption properties of keloids should be enhanced through physiotherapeutic procedures. During the treatment session you should not sunbathe or engage in cryotherapy.

Treatment method

The gel is applied to the affected area of ​​the skin. The dosage should correspond to the following indicators: 0.5 cm of product per 20-25 cm 2. Use 2-3-4 times/day. for a month or more, depending on the lesion and its depth. Coarse scars, joint contractures, and complex postoperative cases require longer use of Contractubex, with the course varying from 2-3 months to six months. The duration of treatment is determined by the attending physician.

How to use the medicine correctly

Gel activator

Despite the fact that the drug is over-the-counter, it is best to use it after consultation with a dermatologist.

It can be used in three ways:

1. Application method.
2. Electrophoresis method.
3. Phonophoresis method.

You should start using the gel no earlier than 14-21 days after the wound has completely healed. The best effect is achieved only when used on scars that appeared no later than two years ago.

If the scars are not yet mature, then it is best to use the application method, since they are not yet mature enough and dense and the medicinal components penetrate deeper into the scars more easily.

Fermenkol gel is used as follows:

1. Wash the area of ​​application thoroughly with soap.
2. Dry carefully.
3. Apply a small amount of product to the skin in the scar area using gentle circular movements and let it dry.
4. The procedure should be repeated two to three times a day for a month to a month and a half.
5. After a two-week break, the course should be repeated.

When using the phonophoresis method, it involves the use of a pharmacological drug in tandem with a device that produces ultrasonic waves. There are both devices that are used only in hospital settings and for home use.

Thanks to ultrasonic waves, collagen fibers are loosened, gel enzymes penetrate better into the depths of the formation, and the effect of proteolytic enzymes increases. This method is best used for mature scars that are very dense, making it difficult for medicinal enzymes to penetrate. The background cutter cannot be used on immature scars, since ultrasonic waves at this stage, on the contrary, will contribute to their compaction.

The phonophoresis procedure must be carried out daily, the course is at least 10 procedures, and a two-week break must be taken between courses. You can buy Fermenkol gel in a pharmacy without a doctor's prescription.

The rules are as follows:

1. Wash and dry the skin around the scar.
2. Place a hot, but not scalding, dry cloth on the scar area for 4-5 minutes.
3. Apply gel to the surface of the scar.
4. Press the device head firmly.
5. Move the head of the device slowly and effortlessly in a circular motion.
6. It is prohibited to tear off the head of the device during the procedure.
7. During the procedure, the product should not dry out; if necessary, it should be added.

The procedure for children from 3 to 15 years old should last no more than three minutes, and for adults it lasts five minutes.

Phonophoresis is prohibited for use in pregnant women during the 2nd and 3rd trimesters. During the electrophoresis procedure, the drug is used in the form of a powder diluted in 1% potassium chloride, a napkin is moistened with it and the procedure is carried out. The procedure lasts about 20 minutes, about 15 procedures are required.

Fermenkol has a contraindication - an individual allergic reaction to collagenase.

Indications and contraindications for use

It is strictly forbidden to apply the gel to open and bleeding injuries. Treatment with the drug can only be started at least 10 days after the wound has healed. The length of treatment is determined by how large and old the injuries are.

1. For stretch marks that occur after childbirth or under the influence of other factors, the gel is used for 3 weeks.
2. For fresh scars, therapy lasts from 3 to 6 weeks.
3. For fresh scars, the drug is carefully applied to the damaged area of ​​the body 3 times a day. Treatment lasts until the skin condition normalizes.
4. For old scars, the gel is applied in a thick layer to the damaged area of ​​the body and covered with a bandage. Skin treatment is carried out once a day before bedtime. Therapy lasts approximately 6 months.

Drug analogues

Peeling BeautyMed reviews

There is no complete analogue of Fermenkol gel with the same active ingredient and in the same release form. The complex of collagenolytic proteases is also presented in the “Fermenkol kit for enzyme correction”; it is used for the electrophoresis procedure. It contains a dry active substance and a means for preparing a solution of Solactin enzymes, the price is about 1000 rubles per 40 ml.

There are also drugs similar in release form and pharmacological action:

1. Fermenkol Elactin - to restore the epidermis in the area of ​​stretch marks - about 4,000 rubles.
2. Kelo-kot - for the treatment of postoperative scars - from 3900 rub.
3. Contractubex - treatment of hypertrophic, colloidal scars - at least 900 rub.
4. Stratamed - can be used on open wounds - about 1500 rub.
5. Kelotan - therapy and prevention of large scars - from 600 rub.
6. Dermatix - to prevent scarring - about 2500 rubles.

You cannot choose a drug for the treatment of scars on your own; you need to consult a doctor.

Fermenkol components and release forms

Fermencol is available in two dosage forms: powder and gel. The medicine is sold through pharmacy chains; a prescription form is not required to purchase it. Below is more detail about each of the forms and its composition:

1. Gel Fermenkol. The main ingredient of this form is a set of proteolytic enzymes at a concentration of 0.01%, namely collagenolytic proteases. Additional substances include: ammonium sulfate, glycerin, water, methylisothiazolinone and acrylate crosspolymer.
2. Fermenkol powder for electrophoresis. Can be used at home. The set includes two bottles. The first bottle contains a yellow powder, which is proteolytic proteases, 4 mg each. The second container contains Solactin. This is the liquid required to dissolve the first bottle, the volume of the solution is 40 ml. Solactin consists of: water, calcium salt of hydrochloric acid, potassium hydroxide, methylisothiazolinone and citric acid.

Compared to a solution of 0.9% sodium chloride, Solactin has the ability to allow proteolytic enzymes to penetrate deep into the rumen. When preparing a medicine, you can take different amounts of solvent, which allows you to create different concentrations.

New items

Fermenkol Set for electrophoresis in binary packaging

Fermenkol Set for electrophoresis in binary packaging Fermenkol 4 mg, dry active substance: complex of collagenolytic proteases - 100%; lyophilized hygroscopic powder from light yellow to light brown color in a glass bottle. Solactin is a means for preparing a solution of enzymes, 40 ml, transparent liquid in a polymer bottle. Ingredients: water, potassium chloride, calcium chloride, chlorhexidine digluconate, hydrochloric (hydrochloric) acid. Indications: Used in cosmetology, surgery and dermatovenerology for the correction and prevention of the formation of hypertrophic and keloid scars after operations, injuries, wounds, burns, purulent-inflammatory skin diseases, acne (acne). There are no age restrictions, it can be used in children. Contraindications: Individual intolerance to collagenases, hypotrophic scars, stretch marks (“stretch marks” of the skin). Method of application: Electrophoresis Based on the clinical form, age, area and depth of the scar, Fermencol solutions of various concentrations are used. To prepare solutions, use the enzyme solution preparation Solactin. The recommended concentration for the correction of keloid scars is 0.5-1 mg/ml, for hypertrophic scars - 0.1-0.2 mg/ml. The required concentration of the solution is selected based on table No. 1 of the instructions. To carry out the procedure, 1 cm2 of scar tissue is required 0.3-0.5 ml of Fermenkol solution. Moisten a layer of filter paper or gauze with Fermenkol solution and apply it to the scarred area of ​​skin. Place a pad with an electrode soaked in water on top. To avoid burns, the gasket should protrude beyond the boundaries of the electrode around the perimeter. Injection should be carried out from the positive pole (from the anode)! Injection mode: current density is no more than 0.1 mA/cm2 when the scar is localized on the skin of the torso and limbs, and no more than 0.05 mA/cm2 during electrophoresis in the facial area. In children under 5 years of age, during electrophoresis in the facial area, the current density should not exceed 0.01 mA/cm2. The duration of the procedure is 20-25 minutes. After the electrophoresis procedure, you should remain in the room for about 30 minutes. Course duration is 12-15 procedures. Frequency of procedures: preferably every day at the same time of day, but not less than every other day. The interval between courses is 7-10 days. Mechanism of scar reduction: Fermencol has high collagenolytic activity, providing deep hydrolysis of collagen peptide bonds. Hydrolysis of collagen occurs down to individual amino acids. Fermenkol exhibits selective activity against branched molecules of pathological collagen with nodular and vortex folding, characteristic of keloid and hypertrophic scars, and is less active against fibrils of native collagen inherent in healthy connective tissue. Scar reduction occurs due to the destruction of excess collagen. In addition to collagenolytic activity, Fermenkol has general proteolytic activity and the ability to hydrolyze polysaccharides, which has a complex effect on all components of the rumen. In the process of using Fermenkol to eliminate acne (acne) and its consequences, the scar capsule around the inflamed gland is destroyed, which helps cleanse it, reduce the volume of scar tissue and smooth the skin. Dry enzyme product Fermenkol is produced with a special agent for preparing a solution of enzymes Solactin, selected the combination of components of which increases the efficiency of enzyme transport into skin tissue, and potassium ions inhibit the activity of fibroblasts that produce excess collagen. Special instructions: Use no earlier than 2-3 weeks after surgery. Safety: Fermenkol line cosmetics contain active enzymes. If the skin is hypersensitive, they can cause redness, which disappears soon after the end of the course of use. Getting the product into an open wound is not dangerous. If Fermenkol or its solutions, or cream or gel gets into your eyes, rinse them with plenty of water. Keep away from children.Storage conditions: Store in a cool, dry, dark place, do not heat above 40 0C. The shelf life of the prepared Fermenkol solution for electrophoresis is 10 days at temperatures from 2 0C to 6 0C, the solution should not be frozen. Shelf life: 3 years from the date of manufacture. , Russia, 197342, St. Petersburg, st. Kantemirovskaya, 2.

How to use Fermenkol according to instructions

The drug can be introduced into scar tissue through application, phonophoresis and electrophoresis.

Application is the most accessible method of using Fermenkol at home. To carry out this procedure, Fermenkol in powder form must be dissolved in 40-50 ml of physiological solution or distilled water. A napkin moistened with the resulting solution should be applied to the scar area for about half an hour. The procedure must be carried out once or twice a day for a month. If necessary, repeat the course of treatment.

Before using Fermenkol in the form of a gel, it is necessary to clean the damaged area of ​​the skin with a special cosmetic product. Apply the gel with light movements (do not rub). This procedure must be carried out two to three times a day for a month. The break between courses is 10-16 days.

Judging by the reviews of Fermenkol, the best results in treatment are observed when the drug is administered through phonophoresis or electrophoresis.

With phonophoresis, all conditions are created for deeper penetration of collagenolytic enzymes into the affected areas of the skin. Before the procedure, it is necessary to clean the skin area with a special cosmetic product. Administration mode: energy flux density of no more than 300 mW/cm² during phonophoresis in the area of ​​the limbs and torso and no more than 200 mW/cm² during phonophoresis in the face area. Duration of exposure is about five minutes per area. The procedure must be applied 10-12 times daily at the same time of day. The break between courses is 10-16 days.

For electrophoresis, according to the instructions, Fermenkol in powder form should be diluted in a solution of potassium chloride (1% aqueous solution) to a concentration in the solution of 1 mg/ml and then diluted with a weak solution of hydrochloric acid. Moisten a gauze pad with the resulting Fermenkol solution (with a concentration of 0.2 mg/ml), apply it to the scar area and use it for the electrophoresis procedure. Administration should begin with the anode at a current density of no more than 0.05 mA/cm² when the scar is localized in the face, and no more than 0.1 mA/cm² for electrophoresis in the area of ​​the limbs and torso. The procedure must be applied 10-15 times daily at the same time of day. The break between courses is 10-15 days.