Injection plastic surgery to combat local fat deposits and cellulite has recently become increasingly popular. A course of simple and painless procedures corrects volumes in problem areas that are not affected by physical activity or diets, and reduces the appearance of the orange peel effect.
The drug phosphatidylcholine is an excellent injection for weight loss; it is easily tolerated, does not cause complications and does not require rehabilitation after administration, allowing you to immediately return to your normal life.
Causes of fat deposits
Fat deposition and the appearance of cellulite are pathological changes in the human body. The reason for their formation is hormonal disorders and metabolic failures caused by internal and external factors. Among them: lack of physical activity, poor diet and fluid deficiency.
In these situations, fat cells (or adipocytes) begin to accumulate in large quantities, in reserve, and their structure changes. The cell membrane becomes denser, but its contents are not excreted. Such changes affect a person’s figure and health.
What is the difference?
The main difference between Choline and Phosphatidylcholine is that Choline is a quaternary ammonium compound, while Phosphatidylcholine is a choline derivative and consists of both choline and phosphoglyceric acid .
Choline and Phosphatidylcholine are components in the structure of eukaryotic cells. Both play important roles in membrane dynamics and membrane physiology of the cell. Because of their vital role in physiology, these substances are found in dietary supplements.
Content
- Overview and main differences
- What is Choline
- What is Phosphatidylcholine
- Similarities Between Choline and Phosphatidylcholine
- What is the difference between Choline and Phosphatidylcholine
- Conclusion
What is Choline?
Choline is a family of water-soluble quaternary ammonium compounds. Choline hydroxide is known as choline base. It is hygroscopic and therefore often found as a colorless, viscous hydrated syrup that smells like trimethylamine (TMA). Aqueous solutions of choline are stable, but the compound slowly breaks down into ethylene glycol, polyethylene glycols and TMA.
Molecular and chemical structure of Choline
Choline occurs as a cation that forms various salts. Choline is an essential nutrient for humans and many other animals. To maintain health, it must be obtained from the diet in the form of choline or choline phospholipids such as phosphatidylcholine. In humans and most animals, choline is produced in the body, but not enough is produced. Choline is often classified not as a vitamin, but as a nutrient with amino acid metabolism. In most animals, choline phospholipids are essential components of cell membranes, cell organelle membranes, and very low-density lipoproteins. Choline is necessary for the production of acetylcholine, a neurotransmitter, and S-adenosylmethionine, a universal methyl donor involved in the synthesis of homocysteine.
Choline - dietary supplement
Symptomatic choline deficiency—rare in humans—causes nonalcoholic fatty liver disease and muscle damage. An excessive daily dose of 8-20 grams of choline can cause low blood pressure, sweating, diarrhea, and a fishy body odor due to the trimethylamine that is formed during its metabolism.
The metabolism of choline occurs similarly to amino acids. Absorption of choline occurs in the intestines, where they undergo facilitated diffusion. Once in the bloodstream, they are freely transported.
Rich dietary sources of choline and choline phospholipids include chicken egg yolk, wheat germ and meat, especially organ meats such as beef liver. In addition to this, meats, grains, vegetables and fruits are also high in choline.
Choline deficiency is a rare disease in humans. However, it can lead to non-alcoholic fatty liver disease and muscle damage.
What is Phosphatidylcholine?
Phosphatidylcholines are a class of phospholipids that include choline as a head group.
The principle of action of phosphatidylcholine
Phosphatidylcholine is a natural enzyme present in the human body in cell membranes. The main purpose is participation in lipid metabolism. The substance is also found in plant crops, sunflower seeds, chicken egg yolk, and soybean crops. Based on the latter, preparations for cosmetic procedures are produced.
Phosphatidylcholine is a local lipolytic; it does not affect overall body weight, but corrects local problem areas with excess fat. Due to its chemical structure, it affects exclusively fat cells, activating the processes of their destruction, binding fatty acids and removing them from the patient’s body.
Action of phosphatidylcholine
The substance is usually used in combination with deoxycholate. The latter dissolves the membrane of fat cells and facilitates the penetration of active substances into it.
Action of lipolytic Phosphatidylcholine
For aesthetic purposes in cosmetology, Phosphatidylcholine has been used for several decades as a topical lipolytic that can dissolve local fat deposits. Due to its structure, Phosphatidylcholine cannot harm adipocytes, but the beneficial properties of lecithin apply only to those fat cells that have been destroyed.
But it is not so easy to destroy adipocytes due to the dense membrane. Therefore, for better penetration into the cell, it was necessary to add an additional drug to the main drug, which can partially dissolve the fat cell membrane. This substance was deoxycholate, a natural component of bile, which normally disrupts the two-layer structure of adipocyte membranes.
Thus, the combination of two biologically active substances (Phosphatidylcholine and Deoxycholate) makes it possible to first achieve the dissolution of cell membranes, and then obtain an oil-water emulsion in fat cells. The finished drug is available in 5 ml ampoules, where the concentration of the main substance is 5%, and deoxycholinic acid - 2.4%.
Adipose tissue before lipolytic injection and two weeks after phosphatidylcholine injection
Indications
Phosphatidylcholine is used to correct local fat deposits that are not amenable to other influences (physical activity, diet). According to the official instructions, it is used to work in the following problem areas:
- stomach;
- chin and neck;
- cheeks;
- buttocks;
- Hands;
- inner thighs.
If necessary, it can be used to work with other areas. Another indication for the procedure is the need to smooth out the relief of the skin after liposuction and fight cellulite.
How to remove belly and sides? Flat belly cream is the solution!
The stomach and waist in women are often “problem No. 1”; it is very difficult to get rid of accumulated deposits even with the help of special exercises and diets.
A unique product with phosphatidylcholine Modellage, developed specifically for women, will help cope with the problem of extra centimeters and restore shape in the shortest possible time! The composition of the cream is enriched with the strongest lipolytic - phosphatidicholine, which is actively used in mesotherapy and gives pronounced results in the breakdown of fat deposits and removal from their problem areas. The uniqueness of the cream lies in the special formula of phosphatidylcholine, which, with the help of liposomes, penetrates into the deep layers of the skin and has a pronounced fat-burning effect.
There is no longer a need for injections of this lipolytic, because now its penetration has become possible without injections. Thanks to the enriched formula, the cream quickly copes with heavy fats in the abdominal area - and you lose centimeters!
Carrying out injections
Phosphatidylcholine is introduced into the dermis to a depth of 1 to 4 centimeters, depending on the location of the problem area. The injections are easily tolerated and do not cause discomfort and do not require prior anesthesia. Superficial or deep injection is a violation of safety precautions and leads to the development of complications.
The injections are carried out at a distance of two centimeters from each other, the injection sites are pre-marked by the cosmetologist using a special marker. It is not allowed to use more than 0.5 ml in one session. The procedures are carried out in a course of 5 to 15 sessions with breaks of 2 to 3 weeks. Changes are assessed after the first visit to a cosmetologist.
Phosphatidylcholine
Injections of fophatidylcholine (usually 70% PC combined with 4.2% deoxycholate as a solvent and 3% benzyl alcohol as a preservative) can be used to induce lipolysis (or fat dissolution). All three ingredients (but predominantly deoxycholate) are capable of inducing adipolysis following an increase in the concentration of triglyceride-rich lipoproteins. This is likely due to the low number of side effects when taken under medical supervision, but side effects have been noted in clinical studies. The injections were administered to patients suffering from lipodystrophy (impaired distribution of adipose tissue, most often observed in HIV-infected patients). An injection of 20 μg/ml, which was injected into the cells of HIV-infected patients suffering from lipodystrophy, lysed adipose tissue within 4-5 hours. In a trial in patients suffering from gynoid lipodystrophy (cellulite), phosphatidylcholine/deoxycholate injections (4 injections over 8 weeks) promoted fat reduction, although a similar effect was observed when deoxycholate was used separately from phosphatidylcholine. In two pilot studies on the orbital fat pad (the area under the eye), injections of 0.4-0.5 ml phosphatidylcholine had mixed effects, with one study showing a beneficial effect and the other having no effect. The drug also had a beneficial effect on jaw fat, although a similar study was not conducted on a control group (the beneficial effect was noted compared to baseline values). One study looked at visceral adiposis (hard fat surrounding internal organs). As a result of a study on an animal model (dog), a fat-burning effect was noted. Also, the fat-burning effect of the drug was noted in the fatty groin area of rats. Intravenous infusion of phosphatidylcholine is capable of inducing necrosis of adipose tissue in vitro, as well as affecting other cell types; Adipose necrosis can sometimes be observed in animal models, 10) but not consistently. A long-term cost-benefit analysis of the use of phosphatidylcholine/deoxycholate injection has not yet been performed. Injections of a mixture of deoxycholate and phosphatidylcholine are widely used for localized fat loss, as shown in studies aimed at combating lipodystrophy. Phosphatidylcholine likely plays an important role here, but the dosage used in the studies was quite low. Also, the structure of the drug was less optimal, since it was used more for aesthetic fat loss than to combat lipodystrophy, although in theory the drug should affect all fat deposits. A precise cost-benefit analysis has not yet been conducted. Taking phosphatidylcholine orally does not likely have the same effects that were noted with injections.
Contraindications
The use of phosphatidylcholine is allowed only if there are no contraindications to injection procedures and the drug itself. Among them are:
- individual intolerance to the substance;
- cholelithiasis;
- diabetes;
- pregnancy and lactation;
- pathologies of the liver, kidneys;
- internal infectious processes;
- soy allergy;
- violation of the integrity of the skin at the injection site;
- systemic connective tissue lesions.
Injections are not carried out into moles, lipomas and other benign formations due to the risk of degeneration.
Rehabilitation period: complications and recommendations
After injections of the drug, patients experience temporary side effects. Thus, swelling and redness of the skin is a normal reaction to external intervention and confirms the work of the lipolytic. Within 2 - 5 days they go away on their own, without treatment.
If a needle damages blood vessels, bruises or even spider veins may remain on the skin. In the latter case, to correct the side effect, it will be necessary to undergo a laser procedure.
Unfortunately, in addition to side effects, more serious complications, inflammatory processes or soft tissue necrosis, may occur. Their formation is associated with a violation of the technique of carrying out the procedure, introducing the drug into the deep areas of the dermis or muscle. If such complications occur, you must urgently contact a specialist to prescribe treatment.
Special recommendations for the rehabilitation period are usually not given; on the first day, it is not recommended to wet the injection sites or treat them with chemical compounds (creams, ointments). If necessary, the skin is treated with Miramistin or another gentle antiseptic drug. It is acceptable to perform light self-massage at home; it is believed that it enhances the results.
Obtaining phosphatidylcholine in cosmetology
This compound is of natural origin. In cosmetology, soy phosphatidylcholine is most often used. It softens and nourishes the skin layers much better. For cosmetics manufacturers, a separate stage is the stabilization of the substance, since liposome suspensions, which are based on unsaturated phosphatidylcholine, are extremely unstable and quickly oxidize. To prevent this, antioxidants (eg tocopherol) are required. To stabilize a large amount of lipids, the same number of emulsifiers are needed, but they weaken the cosmetic effect. Therefore, innovative DMS technology is used. This is a type of emulsion that is used for cosmetic purposes and allows substances to be stabilized.
Most often they contain soy hydrogenated phosphatidylcholine, squalane, shea butter and triglycerides. The listed components do not interfere with skin functions. DMS is the basis of nourishing and protective creams. Moreover, there is no need to add silicone or mineral oils to the recipe. DMS-based products perfectly smooth, moisturize and strengthen the epidermis. But phosphatidylcholine interferes with the stabilization of dermamembrane structures. The compound inactivates the vast majority of standard cosmetic preservatives.
Considering that they should not penetrate the epidermis in order to avoid the development of its hypersensitivity, glycols and their mixtures (glycerin, pentylene glycol, etc.) are mainly used in cosmetology. Ethanol can also be used, but unlike high molecular alcohols, they provide a moisturizing effect at the same time. Liposomal soups have become the best active ingredients and convenient form of delivery of lecinite as a separate cosmetic ingredient. As a result, the integrity of the lipid bilayers of the skin is not compromised.
Phosphatidylcholine is a natural substance involved in fat metabolism. It is found in mustard, egg yolks, soybeans and sunflower seeds.
Phosphatidylcholine is made from soybean oils and then used for cosmetic purposes. Preparations that contain the substance are used as lipolytic agents, with the help of which the process of binding fats and their removal from the body is started.
Due to its structure, phosphatidylcholine does not dissolve the cell membrane, so deoxycholate is added to it. It is a component of bile acids. The combination of phosphatidylcholine and deoxycholate destroys the membrane of fat cells, emulsifies them and removes them from the body through normal routes.
Photos before and after
Photos before and after No. 1
Photos before and after No. 2
Photos before and after No. 3
Price
Phosphatidylcholine is used as part of meso-cocktails for mesotherapy. The average cost of one session is 1500 - 2500 rubles; to achieve pronounced changes, at least 5 - 7 procedures will be required with breaks of 2 to 3 weeks.
The cost of one ampoule of the drug is 300 - 400 rubles and depends on the manufacturer. If necessary, it can be injected in its pure form, in which case the cost of the procedure will start from 1000 rubles and directly depend on the amount of product used.
