Correction of age-related changes using HYALREPAIR-PRP therapy

HYALREPAIR is a series of injectable preparations for skin bioreparation and complex treatment of osteochondral tissue pathologies in people suffering from musculoskeletal system disorders or regularly experiencing increased physical activity. The product contains synthesized hyaluronic acid in a stabilized form, which is as close as possible in structure and properties to biological fluids of the body. Hyalripayer is actively used in sports medicine, orthopedics, surgical practice (including for the recovery and rehabilitation of patients with partial immobilization of various musculoskeletal segments), as well as in cosmetology to improve skin turgor and increase its elasticity .

Gialripayer

Description of the drug

In terms of its properties, Hyalrepair belongs to chondroreparants. These are slow-acting (cumulative) substances that restore the structure of damaged cartilage fibers and help improve joint mobility. Russian pharmacologists classify Gialripayer as a third-generation chondroreparant, which is a combination product consisting of several components . All products in the Hyalrepair line are based on hyaluronic acid, a substance that is part of a large number of tissues and biological fluids of the human body, including nerve endings, ganglia, epithelium, saliva, vaginal lubrication and joint fluid.

Hyalrepair

The body of a person weighing 65 kg contains about 14 g of hyaluronic acid, but with age its reserves decrease, which negatively affects the condition of the skin, mucous membranes and osteochondral elements. Additional local administration of hyaluronate is necessary for persons who have suffered various injuries, have chronic joint diseases, and are daily exposed to heavy physical activity. With an acute shortage of this acid, not only does the resistance of joints to stress decrease, but also general dehydration of the body occurs, since hyaluronate molecules, binding to specific proteoglycan proteins, retain water, maintaining the elasticity of cartilage elements and skin.

4 reasons for aging

Hyalripayer preparations are produced in the form of a gelatinous jelly-like material (gel), packaged in syringes (1.5%) or vials (0.8%). Before packaging, the gel is sterilized in a special way, and a sticker is inserted into the blister, which then must be attached to the patient’s medical card indicating the concentration, dosage of the administered substance, as well as the date and time of administration.

The product must be stored at room temperature, avoiding overheating (above 25°C) and freezing. After opening the bottle, it is permissible to store the gel in the refrigerator for 12 hours.

Biorevitalization areas

Note! The gel in a syringe or bottle must have a uniform consistency (the drug has no color and must be completely transparent). The presence of sediment, flakes, lumps, as well as clouding or yellowing of the gel is a contraindication for use and may indicate improper storage, damage to the packaging or expiration.

Facial bioreparation

Administration technique

In accordance with the instructions, the technique for administering the drug is as follows:

• cleansing the skin of cosmetics;
• application of painkillers;
• administering the medication with a sterile syringe or roller;
• use of antiseptic ointments.

The drug in an open bottle can be stored for no more than 12 hours at a temperature of +2 to +8 degrees.

The bioreparation session can be seen in this video:

What not to do after the procedure

To eliminate negative manifestations after a session until complete rehabilitation, cosmetologists advise avoiding:

• visits to the bathhouse and swimming pool;
• fitness classes;
• sunbathing;
• drinking alcohol.

The duration of recovery, according to statistics, does not exceed 3 days.

How long does the effect last?

After the first course of bioreparation, the effect lasts up to 9 months. In the future, to maintain the result, experts advise conducting sessions once every 6 months.

Reviews from patients and cosmetologists about the drug Hyalrepair

Ksenia, 42 years old, Yuzhno-Sakhalinsk:

Recently I have been using the mesoprocedure product Hyaluform Mesolift. This year, a new domestic product, Hyalrepair Vitasomecomplex, was advertised in a beauty salon. I read the description and decided to try it. On the first day after the session, my face looked like it had chickenpox, with redness and swelling. After 3 days, all the negative phenomena passed and you could look at yourself in the mirror with pleasure. Fine wrinkles smoothed out, complexion improved. My friends say that I look 5 years younger.

Violetta, 34 years old, Birobidzhan:

From an early age, my skin was dry and I constantly used moisturizing cosmetics because I was afraid to inject medicine. With age, wrinkles appeared, and I went to a cosmetology clinic. Experts advised using bioreparation. We did 3 sessions with a break of 2 weeks. The painful sensations were similar to mosquito bites. Side effects in the form of edema and papules disappeared after 4 days. Small wrinkles smoothed out, the skin became moisturized and the face brightened. The manufacturer guarantees that the effect will last up to 9 months.

Margarita, 52 years old, Arkhangelsk:

I used biorevitalization before, but on the advice of a mesotherapist friend with extensive experience, I took a course of injections with Gialripayer. Anesthetic cream was applied before the session, but it still hurt. The next day there were spots on the face after the injections, but after 2 days they went away. My husband wanted to prohibit injections, but when he saw my fresh face he was very pleased.

Claudia, leading cosmetologist, 15 years of professional experience:

The drug has a good composition and effect. It needs to be pricked a little deeper in comparison with analogues, then the result will be better. Thanks to Russian manufacturers for a high-quality cosmetic product.

What's in it?

Hyalripayer is available in several dosage forms, differing not only in the concentration of the main active ingredient (hyaluronic acid), but also in composition.

Table. Composition of Hyalrepair preparations.

The effect of hyaluronic acid on joints

The preparations Gialripayer-2 and Gialripayer-10 differ from each other not only in composition, but also in the modification of hyaluronic acid, which is included in their composition. In Hyalripayer-2, hyaluronic acid is used in the form of sodium hyaluronate, modified with a copolymer of ascorbic acid and magnesium, which has pronounced antioxidant properties. In the production of Hyalripayer-10, zinc hyaluronate and sodium ascorbyl phosphate are used, which are characterized by higher biological stability and a strong anti-aging effect, which explains the high demand for this dosage form in the cosmetology industry.

Damaged skin and skin rich in hyaluronic acid

A stabilized form of highly purified hyaluronic acid is extracted by bacterial fermentation followed by the addition of highly active substances that enhance the effect of the main component: glycine, heterocyclic amino acids, vitamins, etc.

Description of the drug line

There are two lines of the drug "Hyalripayer" in the world - one solves the problem of bioreparation, the second - mesolifting.

The line of bioreparation products is intended for clients of middle and older age groups and has the following effects:

1. Activates the regeneration of dermal cells, replenishes reserves of useful and nutritious substances.
2. The visible signs of photoaging and biological aging of the skin are corrected.
3. They help eliminate not one, but several aesthetic problems.
4. Promote a longer and more pronounced rejuvenation effect.

Below are those modifications of “Hyalripayer” that are used as bioremedies.

Gialripayer-02

Available in the form of a 1.5 ml syringe.

The product contains: hyaluronic acid (14 mg/ml) with added lysine, proline, ascorbic acid and glycine.

Indications:

1. Reducing involutional changes in the skin.
2. Additional hydration.
3. Increased skin tone on the abdomen, shoulders and thighs.
4. Leveling of scar changes.
5. Preparing the skin for aggressive influences: laser rejuvenation, acid peels, plastic surgery.

The bioreparant activates the synthesis of elastin and collagen fibers, and also provides the skin with the substances necessary for this process.

Gialripayer-04

The release form is similar to the previous drug.

Molecule structure: hyaluronic acid (14 mg/ml), ascorbic acid, glutathione, cysteine.

It is used to eliminate any damage to the skin, as well as for the purpose of:

1. Improved tone.
2. Fighting expression wrinkles.
3. Improved complexion.
4. Reduces the severity of hyperpigmentation.
5. Treatment of rosacea.

The product stimulates the formation of elastin and collagen and has an antioxidant effect.

Gialripayer-08

Available in the form of a 1.5 ml injection syringe.

Ingredients: 14 mg/ml hyaluronic acid, L-carnitine and vitamin C.

Application:

1. To correct involutional changes in the skin.
2. With a combination of age-related skin changes and excess fat deposits on the face or torso.
3. To combat excess fat in the cheeks and chin area.
4. In order to increase the tone of the skin after liposuction and as a complement to the course of anti-cellulite therapy.

The drugs used for mesolifting differ from bioremedies in the form of release, volume, composition and amount of hyaluronic acid in 1 ml of solution. They are intended for clients with pronounced age-related skin changes, as well as for young clients suffering from acne.

Gialripayer-06M

Available in 5 ml bottles.

The product consists of hyaluronic acid 2 mg/ml, vitamin C and raboflavin.

It is applied for:

1. Combating decreased firmness and elasticity of skin tissues, which are combined with inflammatory processes.
2. Acne treatment.
3. Reducing the severity of atrophic scars.
4. Extra hydration.

Gialripayer-07M

5 ml bottles contain a complex of substances: 2 mg/ml hyaluronic acid, ascorbic acid, cysteine, valine and glycine.

Used in the following cases:

1. Sensitive, flaky and irritation-prone skin.
2. Sluggish, flabby, dehydrated skin.
3. The presence of wrinkles of varying degrees of depth.
4. Scarring.

This drug can be used together with peeling, laser resurfacing, and even in combination with plastic surgery.

Gialripayer-08M

5 ml bottles.

Ingredients: 2 mg/ml hyaluronic acid, ascorbic acid, L-carnitine.

Indications:

1. Fat deposits in the correction area, which occur in combination with biological aging of the skin.
2. Fat in the chin area.
3. Excess lipid tissue around joints.
4. Treatment of cellulite.
5. Violation of skin turgor and elasticity after removal of fat deposits.

Gialripayer-10M

5 ml bottles containing the following complex of substances: HA – 2 mg/ml, vitamin C, glutathione and cysteine.

It is applied for:

1. Eliminate signs of biological aging.
2. Acne therapy.
3. Restoring the tone and elasticity of the skin.

Component Properties

The main component of Hyalripayer preparations is hyaluronic acid. This is the most important acid present in the human body and is necessary to maintain normal fluid balance and preserve the structure of bones, cartilage fibers, synovial fluid, epidermis, epithelial and connective tissue. It has a number of medicinal properties:

• participates in the processes of regeneration (restoration) and tissue renewal;
• ensures the synthesis of chondrocytes - the structural components of cartilage tissue;
• maintains the elasticity of the skin, ligaments and cartilage;
• ensures normal joint mobility;
• protects the skin from premature fading and aging, and also prevents the accumulation of radioactive and toxic elements in its surface and deep layers;
• interacts with cell surface receptors;
• participates in the formation of innate immunity in the fetus.

Advantages of bioremediation

It has been proven that maintaining sufficient molecular weight of hyaluronate in cartilage tissue in people over 40 years of age significantly reduces the risk of fractures and degenerative damage to the musculoskeletal system, and adequate supply of hyaluronic acid prevents the development of skin tumors (including malignant neoplasms).

The amino acids and ascorbic acid included in Hyalripayer preparations also have antioxidant, immunostimulating, anti-inflammatory and bioreparative effects. Injections of Hyalrepair-2 and Hyalrepair-10 have a positive effect on the condition of the skin: its elasticity increases, the contour improves, and turgor pressure changes. Vitamin C stimulates the synthesis of collagen and elastin - the main elements of the skin that ensure its elasticity and prevent the early appearance of wrinkles.

Hyalrepair-2 and Hyalrepair-10 injections have a positive effect on skin condition

Important! With the local administration of Gialripayer preparations, a physiologically favorable environment is created for the natural stimulation of the metabolic activity of cells, that is, the effect of these chondro- and bioreparants is cumulative (prolonged).

Benefits of HYALREPAIR-PRP therapy

• Maximum implementation of plasma-associated effects.
• Immediate effect (moisturizing and increasing turgor, improving complexion).
• Uniform integration of HYALREPAIR-PRP matrix gel components with growth factors between the fibers of the dermis (not only at the site of the injury itself, but also around) and subsequent obtaining a uniform stimulating effect.
• Direct stimulation of the synthesis of collagen, elastin and glycosaminoglycans.
• Prolonged action (maintaining processes initiated by growth factors at the physiological level for a long time).
• Expanding the possibilities of the procedure due to the additional effects of HYALREPAIR-PRP matrix gel (rosacea, pigmentation).
• Reduced risk of side effects (due to the antioxidant effect, hyperemia subsides faster, the risk of exacerbation of acne is significantly reduced).
• Increasing the safety of autoplasma therapy (binding and neutralizing “cellular debris” of plasma).
• Reducing the volume of blood plasma required for the procedure (one tube instead of four).
• Possibility of using any existing centrifuge (no need for a special centrifuge).

The HYALREPAIR-PRP therapy procedure is indicated for:

• Age-related changes in the skin (decreased turgor and elasticity, wrinkles of varying depths, deformation of the oval of the face).
• Signs of photodamage.
• Dry skin.
• For sensitive skin and disorders of the lipid-epidermal barrier.
• For the treatment of rosacea.
• For hyperpigmentation.
• For skin damage after aggressive influences.
• For the treatment of edema of various etiologies.

The purpose of HYALREPAIR-PRP therapy: increasing skin turgor and tone, reducing the severity of wrinkles and folds, lifting the oval of the face, improving skin color, increasing drainage.

Recommended course: 1-3 procedures, depending on indications and goals. Interval between procedures: 3-4 weeks.

Indications for use

The nosological classification of chondroreparants based on modified stabilized hyaluronic acid contains a large list of indications for use (as part of complex therapy), which includes the following diseases and pathologies:

• neuropathies of the upper and lower extremities;

Ulnar nerve neuropathy

• spinal cord compression syndrome (including diagnostically unspecified forms);
• inflammation of skeletal muscles;
• injuries and surgical interventions on various segments of the musculoskeletal system (including during postoperative rehabilitation);
• damage to the capsular ligamentous apparatus;
• carpal tunnel syndrome (if it is necessary to relieve trigger points);
• dystrophy and degenerative lesions of ligaments, muscles, connecting elements, tendons and cartilage (inflammatory and non-inflammatory etiology);
• bursopathy;
• arthritis and arthrosis.

Arthritis

For the treatment of arthritis, arthrosis of the hip and knee joint, as well as post-traumatic arthrosis, Hyalripayer-10 is used in injection form (syringe) with a concentration of hyaluronic acid of 1.5%.

In cosmetology, the product is used to restore skin elasticity and treat wrinkles.

In cosmetology, the product is used for facial rejuvenation

Sales and storage

The storage temperature of “Hyalrepayer-10” is in the range from 5 to 10 C.
You can buy certified “Hyalrepayer-10” only in the pharmacy chain. Chondroreparant should not be frozen. Store at a temperature of 5 to 10 degrees. The syringe comes with instructions; you must follow its instructions. Do not use medicine that has expired or if it was stored in inappropriate conditions.

Application of bioreparants Hyalripayer in cosmetology

The products in the Hyalrepair line have not only medical, but also cosmetic indications for use. In cosmetology, the product is used as a biologically active bioreparant - a natural stimulator of skin renewal and rejuvenation processes. The choice of a specific solution is determined by the purposes of use and the clinical effect that is expected to be achieved after a course of injections.

Table. The result of using bioremedies Hyalripayer.

Note! All products in the Hyalripayer line are suitable for correcting age-related skin changes and skin rejuvenation.

HYALREPAIR-08 | GIALRIPAYER-08 / bioreparant

Stimulates the synthesis of collagen and elastin fibers, ensures targeted delivery of active substances and promotes their retention in the skin for 3 weeks. L-carnitine strengthens cell membranes and normalizes the water-salt balance of the skin.

Release form

Syringe 1.5 ml

Compound

Hyaluronic acid (14 mg/ml), modified with vitamin C and L-carnitine.

Indications

1. Involutional changes in the skin of the face and body (wrinkles, folds, etc.).

2. Involutional changes in the skin combined with excess fat deposits in the face and body.

3. Local fat deposits in the chin and cheek areas.

4. Ptosis and sagging skin of the shoulders, hips, and anterior abdominal wall in patients due to volume loss during the correction of excess fat deposits;

5. After and in addition to liposuction, injection lipolysis, and the use of the MLS device.

6. In addition to the course of anti-cellulite therapy.

Action

Stimulates the synthesis of collagen and elastin fibers, ensures targeted delivery of active substances and promotes their retention in the skin for 3 weeks. L-carnitine strengthens cell membranes and normalizes the water-salt balance of the skin.

Clinical effects

Skin rejuvenation, reduction in the thickness of subcutaneous fat, accompanied by simultaneous lifting of the oval of the face, reduction of the double chin, lifting of facial and body tissues.

Skin bioreparation

Bioreparation arose as a logical continuation of biorevitalization. It aims to accomplish a much more complex task than moisturizing the skin and smoothing out wrinkles. The goal of this newest injection technique is to force the skin to rejuvenate on its own. Bioreparation has been highly praised by recognized world experts in the beauty industry, and demand for it among clients is steadily growing. However, among professionals this innovative method of rejuvenation has not yet become as widespread as mesotherapy and biorevitalization. By including a bioreparation course in the list of services in your salon, you will give your cosmetology business a powerful incentive for development.

Bioreparation with hyaluronic acid

Specially developed bioremediation preparations contain hyaluronic acid with active substances “sewn” to it, which allow it to remain in the skin for three weeks, and this is an absolute record among all injectable analogues. During this period, hyaluronic acid manages to activate neocollagenesis and proliferation of fibroblasts in the skin - that is, it starts the process of its natural self-rejuvenation. The bioreparation course consists of only three sessions, which makes it affordable and attractive for busy residents of big cities.

How to use Hyalrepair?

Regardless of the form of release, Hyalrepair preparations are used for local (topical) administration directly to the affected area.

Types of Hyalrypyera

Gialripayer 0.8%

Preparations with a concentration of the active substance of 0.8% must be injected directly into the tendon canal or the area of ​​​​damage to the ligamentous apparatus. Before administration, the doctor must assess the degree of damage, as well as the condition of the surrounding soft tissue. In the presence of effusion (excessive accumulation of fluid), it is necessary to first drain the synovial cavity in order to remove excess fluid.

It is permissible to administer no more than 0.5 ml of solution at a time. The standard therapeutic dosage for musculoskeletal pathologies of moderate severity is 0.25-0.4 ml. The course of treatment is 1.5-2 months. The interval between injections is no more than two weeks.

The interval between injections should not exceed 2 weeks

Gialripayer 1.5%

The technique for administering the chondrorepair drug with a concentration of 1.5% is the same as for Hyalrepair 0.8%. Dosage per injection – 2 ml (1 full syringe). The interval between injections is 10-14 days. To achieve a stable therapeutic effect, it is recommended to complete the full course of treatment, which ranges from 1.5 to 2 months, that is, 3-4 injections need to be given in one course. Repeated treatment is carried out after 8-12 months, taking into account the dynamics of the changes that occur.

Note! Hyalripayer preparations do not have a systemic effect on the body and act only at the injection site.

The drug acts only at the injection site

Gialripayer 1.4%

Preparations with a hyaluronic acid concentration of 1.4% are administered once a week. The full course consists of three injections, that is, it lasts 14 days (the interval between injections is 7 days).

Gialripayer 0.6%

For the treatment of acne, xerosis of the skin, seborrhea of ​​the scalp, injections of Hyalrepair 0.6% are performed once every 2 weeks. To achieve a significant clinical effect, it is necessary to undergo at least three procedures. Pronounced health and cosmetic results are achieved after 4-5 procedures.

Dry facial skin

Composition and purpose of bioreparant

Unlike biorevitalization, bioreparation Hyalripayer is a more advanced method of improving skin condition.

In addition to HA (hyaluronic acid), bioremediation preparations contain a complex of additional substances that stimulate tissue renewal, are a building material for skin cells and perform other useful functions.

The purpose of bioreparation is to improve the appearance and launch the mechanisms of skin renewal using the body’s own forces, using active substances supplied to the cells.

The Hyalripayer line of drugs includes 5 varieties , three of which are used in cosmetology, and two for medical purposes.

The vitasomal complex Hyalripayer, in addition to solving aesthetic problems of skin and hair, is used for psychosomatic correction. In this case, injections are made into biologically active points of the body.

As a result, mood improves, sleep normalizes, the activity of internal organs and systems, immunity strengthens, and performance increases.

Vitasomal complex preparations are used in programs such as Health Beauty, Liposlim, Detox and Superlift.

Composition of the Hyalripayer product line and use in cosmetology, dentistry, and treatment of joint diseases:

Portability

In most cases, when administered locally (perineural or periarticular), the drug is well tolerated by all groups of patients. In rare cases (mainly after intramuscular injections), patients reported pain, swelling, a burning sensation and allergic reactions at the injection site. During the day after the injection, a feeling of heat or warmth may also persist: such a reaction is normal if nothing else bothers the patient and does not require any corrective measures.

Important! Some patients ask to numb the injection site before administering the drug, which should never be done. Official instructions do not allow the administration of any drugs 72 hours before the injection and within 48 hours after the injection. This is necessary to achieve a stable therapeutic result, since the drug interaction of hyaluronic acid with other substances has not been well studied.

The main effects of the drugs in the line

Possible contraindications

Limitations for the use of Hyalrepair chondrorepairs are associated primarily with the features of using the gel, and not with its composition, since hyaluronic acid is a natural component of body tissues and fluids and has extremely low rejection. Injections should not be administered to pregnant and lactating women, as well as to persons suffering from allergies or intolerance to any of the components of the drug.

The drug has its contraindications

Other contraindications may include:

• any history of autoimmune diseases (autoimmune hepatitis, antiphospholipid syndrome, Sharpe syndrome, acute disseminated encephalomyelitis);
• carrying out autoimmune treatment, as well as radiation or chemotherapy;
• diseases of the hematopoietic system, accompanied by pathological fragility of blood vessels and increased bleeding;
• infectious skin diseases;
• inflammatory diseases of the joints of septic etiology.

Histological study of the reaction of animal connective tissue to the introduction of modified HA formulas

It is not recommended to administer Hyalrepair gel material in case of severe intoxication syndrome, hyperthermia, signs of fever and systemic infections (bronchopulmonary diseases, infectious bone lesions, bacterial myositis, etc.).

What should the patient know?

Injections Gialripayer-2 and Gialripayer-10 are prescribed mainly by a doctor. Before consenting to the procedure, the patient should familiarize himself with possible contraindications, as well as receive general instructions regarding preparation for the injection and behavior after the injection.

1. Throughout the entire course of treatment (about 6-8 weeks), the consumption of alcoholic beverages, even those with low ethyl alcohol content, is prohibited. Ethanol disrupts the process of cellular metabolism, which makes the therapy ineffective and pointless.

   
   The drug is quite expensive

2. The introduction of any medications (including drugs for local and systemic anesthesia) into the affected area is prohibited until the end of the course of treatment.
3. After the injection, it is necessary to follow a gentle regimen and limit the load on the damaged area. Ideally, you should maintain limited bed rest for 1-2 days after the injection.

   
   After the injection you should remain in bed

All medications that the patient takes regularly or took within two weeks before the injection must be reported to the attending physician.