Correction of scars with LONGIDAZE

Hyaluronic acid is widely used in aesthetic medicine. It is used to smooth out wrinkles, give tissues the missing volume, correct the shape of the face and lip shape, moisturize and rejuvenate the skin.

Hyaluronic acid is a polysaccharide found in connective tissue. This substance is responsible for the firmness and elasticity of the skin. It is also present in the umbilical cord, eyes, and synovial fluid.

The body of an adult contains on average about 10 - 15 g of hyaluronate. At the same time, the body continues to continuously consume and synthesize hyaluronic acid - on average, about 5 g of this substance is consumed per day and the same amount is formed.

The production of hyaluronate occurs in special cells responsible for skin renewal - fibroblasts. At a young age there are many of them, so the dermis of a young person is elastic and elastic. Over the years, both the number of fibroblasts in the body and the produced hyaluronic acid decreases. The skin loses elasticity and becomes flabby. In addition, since fibroblasts are also responsible for the production of collagen and elastin fibers, the skin loses its elasticity and sags.

A gradual decrease in the number of fibroblasts in the body begins at 25–30 years of age. According to scientists, with each passing decade, the number of fibroblasts in human tissue decreases by 10%.

Thus, skin aging is a natural process that cannot be avoided. But no one wants to put up with this, especially a woman. Moreover, the cosmetology services market offers a lot of methods to restore youth and stop the aging process. One way is to inject hyaluronic acid.

Pharmacological properties

The drug Longidaza promotes:

• eliminating swelling;
• reducing the inflammatory process;
• resorption of adhesions;
• protecting cells from exposure to various factors;
• strengthening the immune system.

The greatest effect of the drug Longidaza was recorded at the initial stages of the onset of the pathological process.

Glycosaminoglycans are elements that are constituent elements of connective tissue. As a result of improved metabolic processes, the viscosity of glycosaminolicans is significantly reduced, as a result of which:

• tissue permeability and nutrition increases;
• swelling and hematomas are eliminated;
• joint mobility increases;
• adhesions are eliminated;
• the elasticity of the epidermis improves.

The antioxidant effect of the drug Longidaza occurs due to the ability of the main component to bind iron ions.

The drug Longidaza coordinates the synthesis of inflammatory mediators, helping to weaken the acute period of the inflammatory process, and also increases the body's resistance to various infections and viruses.

The medicine facilitates the postoperative period, helps to weaken the infectious process, and has a positive effect on the processes of bone tissue restoration. All these properties make it possible to use the medication as a prophylactic drug against the occurrence of rough scars and adhesive formations, which very often arise as a result of surgery.

When used in combination, Longidaza enhances the absorption of other medications and helps accelerate the effects of anesthetic (painkillers) drugs.

Longidaza is a low-toxic drug and has a positive effect on the functioning of the reproductive and immune systems.

When the drug is administered intramuscularly, the constituent components enter the bloodstream. The highest amount in the blood plasma is observed 20 minutes after the intramuscular injection. The half-life of elimination from the body is two days. The main part of the drug is excreted through the kidneys. The time for complete elimination is about five days.

Indications

The drug Longidaza is widely used in various medical fields for the treatment of the following diseases:

• septic inflammation of the uterine wall;
• limited mobility and inflammation in the joints;
• accumulation of blood due to closed and open injuries to organs and tissues;
• burns;
• purulent lesion of the epidermis;
• thin strands of connective tissue formed between the walls of the uterus;
• infertility resulting from dysfunction and structure of the fallopian tubes;
• preventing the occurrence of adhesions;
• chronic inflammation of prostate tissue;
• narrowing of the urethra;
• pathological curvature of the penis during erection;
• inflammatory non-infectious disease of the bladder;
• lesions of the skin, characterized by the formation of white stripes, spots, scars;
• a progressive inflammatory process developing on the walls of the alveoli and connective tissue of the parenchyma;
• hardening of the lungs and reduction in their size and volume;
• comprehensive treatment of tuberculosis;
• diffuse interstitial pulmonary fibrosis;
• wounds that do not heal for a long time;
• therapy and prevention of adhesions after surgery on the peritoneal organs.

Reviews from doctors and patients

Miroshnichenko V.P., gynecologist, Saratov

Lidaza and Longidaza are enzyme preparations that have antioxidant, immunomodulatory and anti-inflammatory effects. I use Lidaza and Longidaza in the treatment of adhesions and inflammation in the pelvic organs; the drugs are highly effective and have virtually no side effects. When exposed to a bacterial infection, I prescribe antibiotics together.

Natalya, 45 years old, Moscow

Lidaza was prescribed after an injury, which resulted in contracture of the hip and knee joints and limited mobility in these places. I completed the course of treatment with the drug 2 times, I liked the effect, movements in the joints became less painful, and greater mobility appeared. I am satisfied with the drug, I recommend it for use by those who have such problems.

Contraindications

The instructions for use describe that the drug Longidaza is strictly prohibited from being used in the following situations:

• allergic reactions to components that make up the medicine;
• the presence of infectious diseases and inflammatory processes that are in the progression stage;
• discharge of blood with sputum during coughing;
• complications due to various ailments that are accompanied by bleeding from the bronchial and pulmonary vessels;
• disruption of the normal function and functioning of the kidneys;
• malignant tumor formations;
• children under 18 years of age;
• period of bearing a baby;
• lactation.

Removing filler with Longidase

Hello! I would like some advice, I’m very worried. In 2015 I had lip augmentation done with hyaluronic acid, it was not very successful, I did the correction only a year later and in 2020 I used the drug again. They put it in such a way that in some places the drug bulged out into transparent blue lumps, one was large, there were some white veins on the lip, spots that did not go away over time. The cosmetologist said that everything would go away over time, but it didn’t. Now I decided to remove everything completely, the first Longidaza injection was two days ago, the swelling subsided within an hour, it was almost gone. The gel has become softer, in some places it has gone away, but what worries me is that the places where there were lumps and white spots are stretched, wrinkled, somehow whitish, the skin of the lips seems to be sagging. A week later, another removal procedure. Please tell me, does it take some time for the lips to recover? So that the skin becomes elastic again and takes its shape? Or have I ruined them forever? Thank you very much in advance for your answer!

How to use

Before directly performing an intramuscular or subcutaneous injection, it is necessary to prepare a solution. To do this, you need to take a bottle of medicine and add one of the medicines to it, namely:

The solvent must be introduced very smoothly to avoid excessive agitation and foaming of the lyophilisate.

The resulting composition must be used as quickly as possible. It is strictly forbidden to store the resulting solution for a long period of time due to the fact that the medication loses its medicinal properties.

The duration of therapy, the required dosage, as well as the number of injections are prescribed by the attending physician individually for each patient. It often depends on the general condition of the patient, age category, as well as the degree and severity of the disease.

For the treatment of diseases of the respiratory system, the drug is administered intramuscularly once every 3-5 days, using a dosage of 3000 IU. The course of treatment is 10 injections.

To eliminate adhesive formations, a medication is prescribed, the dose of which is 3000 IU once a day with an interval of 3-5 days. The number of injections depends on the size and number of such formations and ranges from 7 to 10 times.

To accelerate wound healing, a dosage of 1500–3000 IU is used. Injections are administered at intervals of five days. To achieve the result, you need to perform 10 injections.

Allergy to Longidaza?

I’ve had a rash for 3 weeks now—either pityriasis rosea or allergic urticaria. The only thing I took was Longidaza. The doctor prescribed 5 times after 1 day, then 10 times after 2 days. But I took a little more, even when spots began to appear. Then I noticed that there were more spots after taking it and stopped. The half-life of the drug is about 82 hours. The last dose was that week.

I’ve had a rash for 3 weeks now—either pityriasis rosea or allergic urticaria. The only thing I took was Longidaza. The doctor prescribed 5 times after 1 day, then 10 times after 2 days. But I took a little more, even when spots began to appear. Then I noticed that there were more spots after taking it and stopped. The half-life of the drug is about 82 hours. The last dose was that week.

Overdose

During therapy with the drug Longidaza, an overdose may occur, accompanied by the following symptoms:

• painful feeling of cold;
• fever;
• headache;
• dizziness;
• increased body temperature;
• a sharp decrease in blood pressure.

If the above symptoms occur, you should stop using Longidaza as quickly as possible and seek help from a medical professional. The hospital will prescribe appropriate therapy, which will help to get rid of the symptoms that have arisen very quickly.

Briefly about the main thing

Longidaza is a medicinal product with a wide spectrum of actions, which is used in gynecology, urology, cosmetology, and pulmonology. The molecular medicinal product has anti-edematous, anti-inflammatory, antioxidant and preventive effects. It is used not only during periods of exacerbation of pathologies, but also as a supporting agent for certain chronic diseases. Longidaza is not a toxic product. When the correct dosage is selected, the drug does not cause the development of allergic or adverse reactions, does not provoke the formation of gastric and intestinal pathologies, and does not slow down the healing process after surgery.

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Side effect

During the period of use of the drug Longidaza, in rare cases, the following side effects occur in the patient’s body:

• allergic reactions;
• swelling in the area where the injection was performed;
• increasing the amount of blood supplied to the site of administration of the lyophilisate;
• pain during the injection period.

All symptoms often disappear on their own within a few days. If symptoms do not disappear, you should contact your doctor.

What is hyaluronic acid

Hyaluronate is a complex polysaccharide found in human tissues, including the dermis. It is believed that the body of an adult weighing 70 kg contains approximately 15 g of hyaluronate. This substance has the property of attracting and retaining. Thus, one electrically neutral particle of hyaluronic acid can collect up to 500 water molecules, thus creating volume and elasticity of tissues. In addition, hyaluronate stimulates the production of collagen and elastin fibers, which are the “framework” of the skin.

During the day, about 5g is synthesized in our body. hyaluronic acid and the same amount of the substance is broken down. However, with age, the production of hyaluronate slows down, and the skin begins to lose elasticity and volume. That is why the lack of this substance is a signal of skin aging.

special instructions

If any signs of an allergic reaction occur, you should stop using the drug as quickly as possible.

It is strictly prohibited to introduce liquid into an area of ​​the body where there is a tumor, inflammatory process or infectious lesion.

During the period of completion of treatment, it is not recommended to quickly discontinue the use of the drug Longidaza; to do this, you simply need to reduce the dosage. This procedure is necessary in order to avoid the occurrence of the disease again.

The drug Longidaza is not intended for intravenous administration. After preparing the injection solution, it is necessary to carry out the administration of the drug as quickly as possible.

To significantly increase the effectiveness and bioavailability of certain medications, Longidaza is administered 10 minutes before the procedure for administering the main medication to the same area.

Elderly patients

The drug Longidaza is very often prescribed for patients of an older age category. During therapy, it is necessary to monitor the general condition of elderly patients to avoid the occurrence of unwanted symptoms and the development of pathological changes.

Pregnancy and lactation

During the period of bearing a baby, as well as breastfeeding, Longidaza is not used. If it is necessary to prescribe medication during lactation, the mother should stop breastfeeding as quickly as possible and switch the baby to formula. After you stop using the medication, you can resume breastfeeding after a certain period.

In pediatrics

The drug Longidaza is not prescribed for patients under 18 years of age.

Speed ​​and reaction

During the period of use of the drug Longidaza, there are no special restrictions on driving a car independently, as well as performing activities that require quick reaction and increased concentration.

Hyaluronidase preparations

There is a whole group of enzymes of various origins - Lidaza, Biohyal, Ronidase. In Russia, one of the most used is Longidaza.

Longidaza (Londidaza) is produced by the domestic pharmaceutical corporation NPO Petrovax Pharm LLC. The peculiarity of longidase compared to other manufactured drugs is that the main substance in it is in a stabilized state, which increases its activity, the duration of the reaction in the body and resistance to destructive influences (for example, to prostheses).

Longidase is available in two dosage forms - as a lyophilisate for the preparation of a solution for subcutaneous and intramuscular administration and in suppositories for rectal and vaginal use.

Interaction

The drug Longidaza is often prescribed together with drugs that belong to the following groups:

• antibiotics;
• bronchodilators;
• glucocorticosteroids;
• cytostatics;
• antifungal;
• antiviral;
• antihistamines.

Salicylates, cortisone, estrogens and various antihistamines help to significantly reduce the effects of the hyaluronidase enzyme.

When Longidase is used in combination with anesthetics, the bioavailability increases and the action of the latter accelerates.

The combination of Longidase with medications containing phenytoin, furosemide or benzodiazepine is prohibited.

With alcohol

Today there is no scientifically based data on the effects of alcohol on the drug Longidaza. Doctors do not recommend consuming any alcoholic or non-alcoholic drinks during therapy with the drug. This is necessary in order to avoid the occurrence of various unexpected side effects and pathological situations.